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Monkeypox Vaccine

Two vaccines are available to prevent or lessen the severity of monkeypox for exposed individuals in the United States: JYNNEOS (Imvamune or Imvanex) and ACAM2000. JYNNEOS is the preferred vaccine for the current outbreak of monkeypox. Monkeypox can be prevented if the vaccine is given up to four days after exposure. Vaccine given after four and up to fourteen days after exposure could reduce the severity of the illness but might not prevent the disease.

Most Asked Questions

Vaccine supply for JYNNEOS is increasing in the United States but may be limited in some areas. Some health departments and other clinics will have a limited amount of vaccine for selected high-risk persons. Learn more about the JYNNEOS Monkeypox Vaccine Distribution by Jurisdiction.
During this current outbreak, due to a limited vaccine supply, persons who have been in direct contact with a presumed or confirmed monkeypox are candidates for the vaccine. Some other persons who are candidates for vaccine include persons who have male-to-male sexual contact with other risk factors, including sexual contact with multiple, anonymous, or casual sex partners, treatment for an STD in the last 14 days, more than one partner in the last 14 days who is HIV positive on HIV PrEP or has an immunosuppressive condition.
The JYNNEOS vaccine is a two-dose vaccine series. The two doses are administered four weeks apart for maximum effectiveness. Someone who receives the JYNNEOS vaccine is considered fully vaccinated two weeks after receiving their second dose. The JYNNEOS vaccine does not cause smallpox, monkeypox, or any other disease. Even after getting vaccinated, it is important to continue to take steps to protect yourself from getting sick with monkeypox. Avoid close, skin-to-skin contact, including intimate contact, with someone who has monkeypox.
Most people who receive the JYNNEOS vaccine will have only minor reactions like pain, redness, swelling, and itching at the injection site. In rare circumstances, people may experience muscle pain, headache, tiredness, nausea, chills, and fever.
Previous vaccination against smallpox may provide limited protection since both diseases are from the same family of viruses. People vaccinated against smallpox, in the past, will have some protection against monkeypox. People below the 40-50 age group are unlikely to have been inoculated against smallpox since vaccination ended in the world by 1980. Some people received the smallpox vaccine after 9/11 if they were first responders or medical personnel.

Page last updated: August 4, 2022