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Mosquito-borne Diseases
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Healthcare Providers
Many tick-borne diseases can be difficult to diagnose due to the non-specific signs and symptoms in the early stages of illness. Signs and symptoms can vary from patient to patient and can resemble other, more common diseases. Nonetheless, early consideration of tick-borne diseases in the differential diagnosis and empiric treatment is crucial to prevent severe illness and even death in Rickettsial diseases.
Always take a thorough patient history, including:
- Recent tick bite. Many people do not remember being bitten. Do not rule out a tick-borne infection if your patient does not remember a tick bite.
- Exposure to areas where ticks are commonly found, including wooded areas or brushy areas with high grasses and leaf litter.
- Travel history to areas where tick-borne diseases are endemic.
Health Alert Network (HAN): Consider Tick-borne Disease Testing in Patients with Exposure to Tick Bites
To report a patient with a tick-borne disease, please complete the REPORT Card for Reportable Diseases/Conditions.
For CDC guidance on Lyme disease testing, see the Two-Tier Testing Decision Tree.
CDC: Tick-borne Diseases of the United States: A Reference Manual for Healthcare Providers
For more in-depth education, see the CDC's Toolkit for Healthcare Providers. The toolkit provides the following helpful elements:
Resources
Lyme Disease
- Lyme Disease Prophylaxis After Tick Bite: Video | Fact Sheet
- Guidance for Lyme Disease Serologic Test Results
- Pretest Probability of Lyme Disease Video | Fact Sheet
Spotted Fever
- CDC: Rocky Mountain Spotted Fever, Information for Healthcare Providers
- Healthcare Providers Clinical Diagnosis and Treatment Interactive training module (Continuing Education): English
- RMSF Training Video
- RMSF Physician Pocket Card
Other
Page last updated: August 26, 2026
SEE ALSO:
Infectious Diseases and Outbreaks
Mosquito-borne Diseases
NEED HELP?
Having trouble finding what you are looking for? Use our A to Z Index.

